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In humans, where C-cell GIP receptor expression appears to be lower, this effect may be minimal GIP and thyroid blood flow: Some preclinical data suggest GIP influences thyroid gland blood flow, which could theoretically affect hormone production and levothyroxine absorption in patients with remaining thyroid tissue No adverse thyroid effects in trials: In the SURMOUNT and SURPASS clinical trials, tirzepatide did not produce clinically significant changes in thyroid function tests in participants with normal thyroid function The presence of GIP receptors on thyroid tissue is an area of active research

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AOD9604 is commonly studied in the context of lipolysis, adipocyte signaling, hGH fragment biology, and more recently, cartilage and joint biology in preclinical models

Brunton SA, Mosenzon O, Wright EE Jr